Clinical features of patients with trigonocephaly and mutations of GLI3. (a-c), face (aged 11 weeks), right hand and feet of Patient 1. (d-f), face (aged 3.1 years), hands and feet of Patient 2. (g-i), face (aged 6 years), feet and CT scan of Patient 3. (j-l) face (postoperative, aged 3 years) and feet of Patient 4. (m-o) face (aged 2 weeks), feet and skull radiograph of Patient 5. Note trigonocephalic appearance (a,d,g,i,m), except in Patient 4, who was postoperative (j). Dysmorphic features (narrow, upslanted palpebral fissures, broad flat nasal bridge, downturned corners of mouth) are more marked in individuals with deletions (g,j,m). Postaxial polydactyly of the fingers was present only in Patient 1 (b), and partially duplicated thumbs in Patient 2 (e), but all patients had foot abnormalities (c,f,h,l,n). Note supero-medial extension of orbits on the skull radiograph (o), caused by premature metopic suture fusion.