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Intern Med. 2011;50(4):345-9. Epub 2011 Feb 15.

Malignant vaginal melanoma with metastases to the papilla of Vater in a dialysis patient: a case report.

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  • 1Division of Nephrology and Hypertension, Department of Internal Medicine, Shinrakuen Hospital, Japan. hitoshin@qk9.so-net.ne.jp


Malignant vaginal melanoma is an extremely rare clinical condition, with less than 150 cases reported to date. A dialysis patient had primary vaginal melanoma with metastases to the papilla of Vater. Gastroduodenoscopy revealed a polypoid tumor. Histological findings revealed vimentin, S-100 protein, HMB45, MelanA-positive sarcoma-like cells. This staining pattern indicated that this tumor was a malignant melanoma of the papilla. Analysis of an autopsy specimen of the papilla of Vater revealed metastasis from the primary vaginal melanoma. Metastasis of a malignant tumor to the gastrointestinal tract, especially to the papilla, is uncommon. Melanoma should be considered in the differential diagnosis of primary gastrointestinal tract malignancy.

© 2011 The Japanese Society of Internal Medicine

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