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Curr Opin Genet Dev. 2011 Apr;21(2):199-206. doi: 10.1016/j.gde.2011.01.018. Epub 2011 Feb 14.

Cohesin: genomic insights into controlling gene transcription and development.

Author information

  • Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, United States. dorsettd@slu.edu

Abstract

Over the past decade it has emerged that the cohesin protein complex, which functions in sister chromatid cohesion, chromosome segregation, and DNA repair, also regulates gene expression and development. Even minor changes in cohesin activity alter several aspects of development. Genome-wide analysis indicates that cohesin directly regulates transcription of genes involved in cell proliferation, pluripotency, and differentiation through multiple mechanisms. These mechanisms are poorly understood, but involve both partial gene repression in concert with Polycomb group proteins, and facilitating long-range looping, both between enhancers and promoters, and between CTCF protein binding sites.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21324671
[PubMed - indexed for MEDLINE]
PMCID:
PMC3070859
Free PMC Article

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