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Curr Opin Genet Dev. 2011 Apr;21(2):231-5. doi: 10.1016/j.gde.2011.01.010. Epub 2011 Feb 14.

Promoter proximal pausing and the control of gene expression.

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  • 1Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, United States.

Abstract

The advent of methods for mapping the location of specific proteins across genomes is substantially enlightening our understanding of gene regulation. One recent discovery is that Pol II is concentrated at the 5' end of thousands of genes in mammalian and Drosophila cells. Before this, much research had focused on understanding how sequence-specific, DNA-binding proteins orchestrate the actions of regulators of chromatin structure and the general transcriptional machinery to control transcription initiation. The concentration of Pol II at the 5' ends of genes indicates that key steps regulating transcription occur after Pol II has associated with a gene's promoter.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21324670
[PubMed - indexed for MEDLINE]
PMCID:
PMC3443551
Free PMC Article

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