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J Cell Biol. 2011 Feb 21;192(4):547-56. doi: 10.1083/jcb.201009094. Epub 2011 Feb 14.

Four faces of cellular senescence.

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  • 1The Research Centre of the University of Montreal Hospital Centre/Institut du Cancer de Montréal, Montreal, Quebec, Canada.

Abstract

Cellular senescence is an important mechanism for preventing the proliferation of potential cancer cells. Recently, however, it has become apparent that this process entails more than a simple cessation of cell growth. In addition to suppressing tumorigenesis, cellular senescence might also promote tissue repair and fuel inflammation associated with aging and cancer progression. Thus, cellular senescence might participate in four complex biological processes (tumor suppression, tumor promotion, aging, and tissue repair), some of which have apparently opposing effects. The challenge now is to understand the senescence response well enough to harness its benefits while suppressing its drawbacks.

PMID:
21321098
[PubMed - indexed for MEDLINE]
PMCID:
PMC3044123
Free PMC Article
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