Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Maturitas. 2011 Apr;68(4):322-30. doi: 10.1016/j.maturitas.2011.01.011. Epub 2011 Feb 12.

Immunosenescence: Implications for vaccination programmes in adults.

Author information

  • 1Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Geneva, Switzerland. pierre.o.lang@hcuge.ch

Abstract

Vaccination is crucially important in preventing infection and protecting vulnerable population from infectious diseases. However, a multitude of changes in the immune system occurring with advancing age, termed immunosenescence, lead to limit the protective effects of vaccination in older adults. While it is widely believed that the current immunization strategies saves many lives, vaccine preventable infectious diseases (VPDs) still place a considerable burden, not only on older individuals, but also on the adult population and healthcare systems of developed countries. This review will first examine the evidence linking the contribution of immunosenescence to a less than optimal vaccine response in aged individuals in order to demonstrate that strategy of promoting vaccination in these populations is not sufficient to reduce the burden associated with VPDs. Furthermore, based upon the side effects of the herd immunity when vaccine-policies are mainly childhood-centered, considerations will be given on the imperative necessity to frame shift our thinking and efforts away from a nearly complete childhood-centered vaccine programme toward a life-span immunization programmes.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID:
21316879
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk