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Fertil Steril. 2011 Apr;95(5):1677-83. doi: 10.1016/j.fertnstert.2011.01.130. Epub 2011 Feb 12.

How effective is in vitro fertilization, and how can it be improved?

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  • 1School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia. louise.stewart@uwa.edu.au

Abstract

OBJECTIVE:

To measure IVF effectiveness, which is defined as the cumulative incidence of live delivery over real time in women after commencing IVF treatment.

DESIGN:

Population-based retrospective cohort study.

SETTING:

IVF clinics in Western Australia (WA).

PATIENT(S):

All women ages 20-44 years inclusive at start of treatment, commencing IVF in 1982-1992 and 1993-2002 at clinics in WA (n = 8,275).

INTERVENTION(S):

Data on IVF cycles were extracted from hospital records and a statutory reproductive technology register and linked to records of births.

MAIN OUTCOME MEASURE(S):

Cumulative incidence of an IVF-attributed live delivery and cumulative incidence of an IVF-attributed or IVF treatment-independent live delivery.

RESULT(S):

IVF effectiveness in the 1993-2002 cohort was 47% overall. It was highest in women ages 20-29 years at the start of treatment, measuring 58%; and 79% with the inclusion of IVF treatment-independent deliveries, and declined to 22% and 33%, respectively, in women ages 40-44 years. Couples underwent, on average, only three cycles, even though the cumulative probability of a live delivery increased with each successive cycle for at least the first five cycles.

CONCLUSION(S):

IVF effectiveness could be improved if women, particularly those over 35, underwent more cycles.

Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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PMID:
21316660
[PubMed - indexed for MEDLINE]
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