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J Hepatol. 2011 Jun;54(6):1250-62. doi: 10.1016/j.jhep.2010.11.016. Epub 2010 Dec 8.

Management of hepatitis C virus genotype 4: recommendations of an international expert panel.

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  • 1Department of Internal Medicine, University of Minia, Egypt.


HCV has been classified into no fewer than six major genotypes and a series of subtypes. Each HCV genotype is unique with respect to its nucleotide sequence, geographic distribution, and response to therapy. Genotypes 1, 2, and 3 are common throughout North America and Europe. HCV genotype 4 (HCV-4) is common in the Middle East and in Africa, where it is responsible for more than 80% of HCV infections. It has recently spread to several European countries. HCV-4 is considered a major cause of chronic hepatitis, cirrhosis, hepatocellular carcinoma, and liver transplantation in these regions. Although HCV-4 is the cause of approximately 20% of the 170 million cases of chronic hepatitis C in the world, it has not been the subject of widespread research. Therefore, this document, drafted by a panel of international experts, aimed to review current knowledge on the epidemiology, natural history, clinical, histological features, and treatment of HCV-4 infections.

Copyright © 2010 European Association for the Study of the Liver. All rights reserved.

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