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J Pediatr. 2011 Jul;159(1):99-103.e1. doi: 10.1016/j.jpeds.2010.12.032. Epub 2011 Feb 10.

Melatonin and mental capacities in newborn infants.

Author information

  • 1Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel. ferbers@post.tau.ac.il

Abstract

OBJECTIVES:

To investigate the role of melatonin in the emergence of mental capacities in the newborn infant.

STUDY DESIGN:

Assessment of Preterm Infant Behavior examination was performed at 2 weeks post-term age for 39 (21 preterm and 18 term) infants. 6-Suphatoxymelatonin from nocturnal urine samples was analyzed by enzyme-linked immunosorbent assays, and the Mental Developmental Index, assessed by Bayley scales, was correlated at 4, 6, and 9 months' corrected age.

RESULTS:

Multivariate analysis of variance with repeated measures showed that improved autonomic function at 2 weeks of age was associated with higher Mental Developmental Index scores at 9 months when related to the amount of melatonin at 4, 6, and 9 months of age.

CONCLUSIONS:

Early compromised autonomic system function in preterm infants is associated with lower mental capacities and is related to lower melatonin levels at later ages.

Copyright © 2011 Mosby, Inc. All rights reserved.

PMID:
21315375
[PubMed - indexed for MEDLINE]
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