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J Womens Health (Larchmt). 2011 Feb;20(2):255-61. doi: 10.1089/jwh.2010.2353.

An open label pilot study of transcranial magnetic stimulation for pregnant women with major depressive disorder.

Author information

  • 1Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. drkim@mail.med.upenn.edu

Abstract

OBJECTIVE:

Despite the data that major depressive disorder (MDD) is common during pregnancy and that pregnant women prefer nonmedication treatment options, there is a paucity of research examining alternative treatments for this special population. We present the results of an open label pilot study examining treatment with transcranial magnetic stimulation (TMS) in pregnant women with MDD.

METHODS:

Ten women with MDD in the second or third trimester of pregnancy were treated with 20 sessions of 1-Hz TMS at 100% of motor threshold (MT) to the right dorsolateral prefrontal cortex. The total study dose was 6000 pulses. Antenatal monitoring was performed during treatment sessions 1, 10, and 20.

RESULTS:

Seven of ten (70%) subjects responded (decrease ≥50% in Hamilton Depression Rating Scale [HDRS-17] scores). No adverse pregnancy or fetal outcomes were observed. All infants were admitted to the well baby nursery and were discharged with the mother. Mild headache was the only common adverse event and was reported by 4 of 10 (40%) subjects.

CONCLUSIONS:

TMS appears to be a promising treatment option for pregnant women who do not wish to take antidepressant medications.

PMID:
21314450
[PubMed - indexed for MEDLINE]
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