Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Genet Med. 2011 Mar;13(3):191-4. doi: 10.1097/GIM.0b013e31820f603f.

Downsizing genomic medicine: approaching the ethical complexity of whole-genome sequencing by starting small.

Author information

  • Department of Bioethics and Genomic Medicine Institute, Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA. sharpr3@ccf.org

Abstract

As we look to a time when whole-genome sequencing is integrated into patient care, it is possible to anticipate a number of ethical challenges that will need to be addressed. The most intractable of these concern informed consent and the responsible management of very large amounts of genetic information. Given the range of possible findings, it remains unclear to what extent it will be possible to obtain meaningful patient consent to genomic testing. Equally unclear is how clinicians will disseminate the enormous volume of genetic information produced by whole-genome sequencing. Toward developing practical strategies for managing these ethical challenges, we propose a research agenda that approaches multiplexed forms of clinical genetic testing as natural laboratories in which to develop best practices for managing the ethical complexities of genomic medicine.

PMID:
21311340
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk