Send to:

Choose Destination
See comment in PubMed Commons below
Phytother Res. 2011 Sep;25(9):1323-7. doi: 10.1002/ptr.3420. Epub 2011 Feb 10.

In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens.

Author information

  • 1College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-Gil, Yongsan-Gu, Seoul, 140-742, Korea.


A new sesquiterpene lactone was isolated from Siegesbeckia glabrescens as an inhibitor of nitric oxide and prostaglandin E2 synthesis in the LPS-activated RAW264.7 macrophage cell line. It dose-dependently decreased the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Reporter gene assay revealed that the compound attenuated the LPS-induced DNA transcriptional activity of nuclear factor-kappa B (NF-κB). In addition, it inhibited the nuclear translocation of the p65 subunit of NF-κB by blocking the inhibitory kappa B-α degradation. This compound from Siegesbeckia glabrescens might be beneficial for the treatment of inflammation-related diseases.

Copyright © 2011 John Wiley & Sons, Ltd.


Siegesbeckia glabrescens; inhibitor; nitric oxide; nuclear factor-κB; prostaglandin E2; sesquiterpenes

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk