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Trends Cell Biol. 2011 Jun;21(6):374-81. doi: 10.1016/j.tcb.2011.01.003. Epub 2011 Feb 8.

Merotelic kinetochore attachment: causes and effects.

Author information

  • 1Max F. Perutz Laboratories, University of Vienna, Dr. Bohr-Gasse 1, 1030 Vienna, Austria. juraj.gregan@univie.ac.at

Abstract

Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction mechanisms, merotelically attached kinetochores can persist until anaphase, causing chromatids to lag on the mitotic spindle and hindering their timely segregation. Recent studies showing that merotelic kinetochore attachment represents a major mechanism of aneuploidy in mitotic cells and is the primary mechanism of chromosomal instability in cancer cells have underlined the importance of studying merotely. Here, we highlight recent progress in our understanding of how cells prevent and correct merotelic kinetochore attachments.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21306900
[PubMed - indexed for MEDLINE]
PMCID:
PMC3117139
Free PMC Article

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