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J Neuropsychiatry Clin Neurosci. 2011 Winter;23(1):107-10. doi: 10.1176/appi.neuropsych.23.1.107.

Abnormal structural correlates of response perseveration in individuals with psychopathy.

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  • 1Laboratory of NeuroImaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA. yaling.yang@loni.ucla.edu


Structural deficits in the frontotemporal network have been shown in individuals with psychopathy and are posited to contribute to neuropsychological impairments such as response perseveration. However, no study to date has examined structural correlates of response perseveration in individuals with psychopathy. In this structural MRI study, the authors found higher correlations between increased response perseveration and reduced cortical thickness in the orbitofrontal and anterior temporal regions in individuals with psychopathy than in healthy-comparison subjects. The findings provide preliminary evidence suggesting potential contributions of frontotemporal structural deficits in neurocognitive impairment with perseveration in individuals with psychopathy.

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