Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Mol Med (Berl). 2011 Mar;89(3):229-36. doi: 10.1007/s00109-011-0731-9. Epub 2011 Feb 8.

Glutamine: pleiotropic roles in tumor growth and stress resistance.

Author information

  • 1Oncology Research Unit, Pfizer Worldwide Research and Development, Pearl River, NY 10965, USA.

Abstract

Tumors and tumor cell lines rapidly consume the amino acid glutamine (Gln) and use it to supply metabolic pathways that support cell growth and proliferation. Much of the research regarding the relationship between glutamine metabolism and cancer is based on the premise that this abundant nutrient represents an important driver of tumor cell anabolism. However, Gln's influence in cell biology and cancer extends far beyond its use as a carbon and nitrogen source for the structural components of dividing cells. Gln is truly a multipurpose nutrient, feeding many additional pathways that boost the ability of cells to communicate with each other and to cope with stress by oncogenic signaling and by the tumor microenvironment. A number of recent reports have highlighted these "non-anabolic" functions of Gln metabolism in regulating cell survival, oxidative stress resistance, signal transduction, and autophagy. Here, we review some of these findings and discuss their relevance to tumor biology and the potential for cancer therapy.

PMID:
21301794
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk