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Biotechnol J. 2011 Feb;6(2):213-23. doi: 10.1002/biot.201000342.

Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis.

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  • 1Department of Chemical and Bimolecular Engineering, North Carolina State University, Raleigh, NC, USA.


TiO₂ films may be used to alter the wettability and hemocompatibility of cellulose materials. In this study, pure and stoichiometric TiO₂ films were grown using atomic layer deposition on both silicon and cellulose substrates. The films were grown with uniform thicknesses and with a growth rate in agreement with literature results. The TiO₂ films were shown to profoundly alter the water contact angle values of cellulose in a manner dependent upon processing characteristics. Higher amounts of protein adsorption indicated by blurry areas on images generated by scanning electron microscopy were noted on TiO₂ -coated cellulose acetate than on uncoated cellulose acetate. These results suggest that atomic layer deposition is an appropriate method for improving the biological properties of hemostatic agents and other blood-contacting biomaterials.

Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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