Neuroreport. 1990 Sep;1(1):17-9.

Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine-dependent rat.

Source

Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.

Abstract

Because of anecdotal reports in which ibogaine eliminates opioid withdrawal symptoms in humans, we studied this phenomenon in the rat model. Ibogaine (5, 10, 20 and 40 mg kg-1, s.c.) was administered 15 min before naloxone (0.5 mg kg-1, s.c.) in morphine dependent rats (3 days after the s.c. implantation of a 75 mg morphine pellet). Of the 12 withdrawal signs scored, the only significant changes observed after ibogaine (compared with vehicle control) was a decrease in grooming (10 mg kg-1) and an increase in teeth chatter (5 mg kg-1). In spite of ibogaine's apparent interaction with several neurotransmitter receptor systems, it does not alleviate opioid withdrawal in this animal model at non-tremorigenic (5 and 10 mg kg-1) or tremorigenic (20 and 40 mg kg-1) doses.

PMID:: 2129850; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Molecular Biology Databases

NALOXONE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Effect of ibogaine on naloxone-precipitated withdrawal syndrome in chronic morphine-dependent rats. [Arch Int Pharmacodyn Ther. 1988]
Effect of ibogaine on naloxone-precipitated withdrawal syndrome in chronic morphine-dependent rats.
Dzoljic ED, Kaplan CD, Dzoljic MR. Arch Int Pharmacodyn Ther. 1988 Jul-Aug; 294:64-70.
Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor. [Neuropharmacology. 1992]
Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor.
Glick SD, Rossman K, Rao NC, Maisonneuve IM, Carlson JN. Neuropharmacology. 1992 May; 31(5):497-500.
Effects of ibogaine on naloxone-precipitated withdrawal in morphine-dependent mice. [Fundam Clin Pharmacol. 1992]
Effects of ibogaine on naloxone-precipitated withdrawal in morphine-dependent mice.
Francés B, Gout R, Cros J, Zajac JM. Fundam Clin Pharmacol. 1992; 6(8-9):327-32.
Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine dependent rat. [NIDA Res Monogr. 1990]
Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine dependent rat.
Sharpe L, Jaffe J. NIDA Res Monogr. 1990; 105:477.
Review [Involvement of the amygdala on place aversion induced by naloxone in single-dose morphine-treated rats]. [Yakugaku Zasshi. 2008]
Review [Involvement of the amygdala on place aversion induced by naloxone in single-dose morphine-treated rats].
Ishida S, Shimosaka R, Kawasaki Y, Jin C, Kitamura Y, Araki H, Sendo T, Gomita Y. Yakugaku Zasshi. 2008 Mar; 128(3):395-403.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine-depend...
Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine-dependent rat.
Neuroreport. 1990 Sep ;1(1):17-9.

PubMed
Transcriptional control mechanisms associated with the nucleotide receptor P2X7,...
Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions.
Immunol Res. 2011 May ;50(1):22-38.

PubMed
Genetic aspects of Wilson's disease.
Genetic aspects of Wilson's disease.
J Gastroenterol Hepatol. 1990 Jul-Aug ;5(4):483-90.

PubMed
Sequencing transcriptomes in toto.
Sequencing transcriptomes in toto.
Integr Biol (Camb). 2011 May ;3(5):522-8. Epub 2011 Feb 4 .

PubMed
Genetic variation among major human geographic groups supports a peculiar evolut...
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9.
PLoS One. 2011 Jan 27 ;6(1):e15656.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: