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Curr Opin Cell Biol. 2011 Jun;23(3):293-301. doi: 10.1016/ Epub 2011 Feb 4.

Nuclear pore complex-a coat specifically tailored for the nuclear envelope.

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  • 1Department of Molecular and Cell Biology, Division of Cell and Developmental Biology, University of California, Berkeley, CA 94720-3200, United States.


Nuclear pore complexes (NPCs) are highly selective transport gates that enable the bi-directional traffic of macromolecules across the nuclear envelope (NE). NPCs are located at the fusion pores between the inner and outer membranes of the NE and are built from a common set of ∼30 different proteins, nucleoporins. Remarkably, recent proteomic, bioinformatic, and structural studies have provided firm evidence that key structural nucleoporins share common ancestry with elements of coated vesicles, indicating an evolutionary link between these structures. This has provided novel insight into the origin of NPCs and may help us to better functionally characterize these fundamental components of eukaryotic cells.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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