Display Settings:

Format

Send to:

Choose Destination
Trends Ecol Evol. 2011 Apr;26(4):175-82. doi: 10.1016/j.tree.2011.01.002.

Peto's Paradox: evolution's prescription for cancer prevention.

Author information

  • 1Genomics and Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA. alefox@mail.med.upenn.edu

Abstract

The evolution of multicellularity required the suppression of cancer. If every cell has some chance of becoming cancerous, large, long-lived organisms should have an increased risk of developing cancer compared with small, short-lived organisms. The lack of correlation between body size and cancer risk is known as Peto's paradox. Animals with 1000 times more cells than humans do not exhibit an increased cancer risk, suggesting that natural mechanisms can suppress cancer 1000 times more effectively than is done in human cells. Because cancer has proven difficult to cure, attention has turned to cancer prevention. In this review, similar to pharmaceutical companies mining natural products, we seek to understand how evolution has suppressed cancer to develop ultimately improved cancer prevention in humans.

Comment in

PMID:
21296451
[PubMed - indexed for MEDLINE]
PMCID:
PMC3060950
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure I
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk