Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 2011 Feb 4;144(3):327-39. doi: 10.1016/j.cell.2011.01.024.

Functional and mechanistic diversity of distal transcription enhancers.

Author information

  • 1Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, NY 14627, USA.

Erratum in

  • Cell. 2011 Mar 4;144(5):825.


Biological differences among metazoans and between cell types in a given organism arise in large part due to differences in gene expression patterns. Gene-distal enhancers are key contributors to these expression patterns, exhibiting both sequence diversity and cell type specificity. Studies of long-range interactions indicate that enhancers are often important determinants of nuclear organization, contributing to a general model for enhancer function that involves direct enhancer-promoter contact. However, mechanisms for enhancer function are emerging that do not fit solely within such a model, suggesting that enhancers as a class of DNA regulatory element may be functionally and mechanistically diverse.

Copyright © 2011 Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk