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Nature. 1990 Oct 18;347(6294):645-50.

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.

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  • 1Imperial Chemical Industries PLC, Central Toxicology Laboratory, Alderley Park, Macclesfield, UK.


We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man.

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