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FEBS Lett. 1990 Apr 24;263(2):299-302.

Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex.

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  • 1Department of Biochemistry, School of Medicine, Keio University, Tokyo, Japan.


Using an oligonucleotide probe designed on the basis of the N-terminal amino acid sequence of purified rat aldosterone synthase cytochrome P-450 [(1989) J. Biol. Chem. 264, 10935] we have isolated from rat adrenal cDNA library a 2687 base pair cDNA that encodes a protein of 500 amino acid residues. The deduced amino acid sequence contained the regions well conserved among all cytochrome P-450s sequenced to date, and also a portion (residues 25-44) which was identical to the N-terminal peptide sequence of rat aldosterone synthase cytochrome P-450. These results indicate that the cDNA encodes a precursor form of rat aldosterone synthase cytochrome P-450.

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