Cell Stem Cell. 2011 Feb 4;8(2):126-7. doi: 10.1016/j.stem.2011.01.004.

A twist of cell fate.

Source

University of California-San Francisco, CA 94143-0506, USA. thea.tlsty@ucsf.edu

Abstract

Individuals carrying deleterious BRCA1 mutations typically develop basal-like rather than luminal breast cancers. In this issue of Cell Stem Cell, Proia et al. (2011) study breast tissue from women with heterozygous BRCA1 mutations and identify molecular mechanisms that regulate mammary progenitor cell differentiation and bias toward subsequent basal-like tumor formation.

Comment on

Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. [Cell Stem Cell. 2011]
Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, Sedic M, Gilmore H, Tung N, Naber SP, Schnitt S, et al. Cell Stem Cell. 2011 Feb 4; 8(2):149-63.