FEBS Lett. 2011 Mar 9;585(5):717-22. Epub 2011 Feb 3.

Nuclear receptors and microRNAs: Who regulates the regulators in neural stem cells?

Eendebak RJ, Lucassen PJ, Fitzsimons CP.

Source

Center for Neurosciences, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands.

Abstract

In this mini-review, we focus on regulatory loops between nuclear receptors and microRNAs, an emerging class of small RNA regulators of gene expression. Evidence supporting interactions between microRNAs and nuclear receptors in the regulation of gene expression networks is discussed in relation to its possible role in neural stem cell self renewal and differentiation. Furthermore, we discuss possible disturbances of the regulatory loops between microRNAs and nuclear receptors in human neurodegenerative disease. Finally, we discuss the possible use of nuclear receptors as pharmacological entry points to regulate neural stem cell self-renewal and differentiation.

PMID:: 21295033; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. [Nat Commun. 2011]
miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells.
Sun G, Ye P, Murai K, Lang MF, Li S, Zhang H, Li W, Fu C, Yin J, Wang A, et al. Nat Commun. 2011 Nov 8; 2:529. Epub 2011 Nov 8.
Review Nuclear receptors in stem cells and their therapeutic potential. [Adv Drug Deliv Rev. 2010]
Review Nuclear receptors in stem cells and their therapeutic potential.
Sun G, Shi Y. Adv Drug Deliv Rev. 2010 Oct 30; 62(13):1299-306. Epub 2010 Aug 11.
Review MicroRNA regulation of neural stem cells and neurogenesis. [J Neurosci. 2010]
Review MicroRNA regulation of neural stem cells and neurogenesis.
Shi Y, Zhao X, Hsieh J, Wichterle H, Impey S, Banerjee S, Neveu P, Kosik KS. J Neurosci. 2010 Nov 10; 30(45):14931-6.
A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. [Nat Struct Mol Biol. 2009]
A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination.
Zhao C, Sun G, Li S, Shi Y. Nat Struct Mol Biol. 2009 Apr; 16(4):365-71. Epub 2009 Mar 29.
MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling. [Proc Natl Acad Sci U S A. 2010]
MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling.
Zhao C, Sun G, Li S, Lang MF, Yang S, Li W, Shi Y. Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5):1876-81. Epub 2010 Jan 19.

See reviews... See all...

Cited by 1 PubMed Central article

New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs. [Front Neurosci. 2012]
New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs.
Schouten M, Buijink MR, Lucassen PJ, Fitzsimons CP. Front Neurosci. 2012; 6:25. Epub 2012 Feb 17.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Nuclear receptors and microRNAs: Who regulates the regulators in neural stem cel...
Nuclear receptors and microRNAs: Who regulates the regulators in neural stem cells?
FEBS Lett. 2011 Mar 9 ;585(5):717-22. Epub 2011 Feb 3 .

PubMed
Health status and lifestyle factors as predictors of depression in middle-aged a...
Health status and lifestyle factors as predictors of depression in middle-aged and elderly Japanese adults: a seven-year follow-up of the Komo-Ise cohort study.
BMC Psychiatry. 2011 Feb 7 ;11:20.

PubMed
International Conference on Advances in Radiation Oncology (ICARO): outcomes of ...
International Conference on Advances in Radiation Oncology (ICARO): outcomes of an IAEA meeting.
Radiat Oncol. 2011 Feb 4 ;6:11.

PubMed
Induction of adaptive response: pre-exposure of mice to 900 MHz radiofrequency f...
Induction of adaptive response: pre-exposure of mice to 900 MHz radiofrequency fields reduces hematopoietic damage caused by subsequent exposure to ionising radiation.
Int J Radiat Biol. 2011 Jul ;87(7):720-8. doi: 10.3109/09553002.2010.550981. Epub 2011 Feb 7 .

PubMed
Steroid therapy in primary glomerulonephritis.
Steroid therapy in primary glomerulonephritis.
Nephrol Dial Transplant. 1990 ;5 Suppl 1:23-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: