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Turk Neurosurg. 2011 Jan;21(1):39-47.

Primary CNS lymphoma in immunocompetent: a review of literature and our experience from Kashmir.

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  • 1Department of Pathology, SKIMS, Kashmir, 190011, India. rumanahamid@rediffmail.com

Abstract

AIM:

To study the clinicopathological aspects of primary CNS lymphoma in immunocompetent patients.

MATERIAL AND METHODS:

Sixteen patients with primary CNS lymphoma were analyzed for their clinico-pathological characteristics and followed-up for the treatment and subsequent management in Neurosurgery, and Medical and Radiation Oncology.

RESULTS:

The fronto-parietal region was the commonest location of CNS lymphoma; four cases of cerebellar lymphoma were seen. Our patients were relatively young with a mean age of 48 years and an age range of 35-60 years. Females outnumbered males with a ratio of 2.7:1. The commonest presentation was focal neurological-deficits and features of raised intracranial pressure. All the patients histologically had diffuse large B-cell lymphoma. Radiologically, most presented as disc-enhancing lesions. Two patients had multiple lesions. Most of the patients (10) died within a mean of 4.4 months (range 2 weeks-16 months).

CONCLUSION:

Primary CNS lymphoma is seen in immunocompetent patients as well. Relapse is common after treatment and the overall prognosis is unfavorable.

PMID:
21294090
[PubMed - indexed for MEDLINE]
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