The cross talk noise-to-signal ratio (NSR) of an angle-multiplexed holographic data storage system is studied, and we propose a method to determine the optimized multiplexing spacing with which the cross talk noise can be less than the conventional method. In our method, the optimization location at the image plane can be chosen arbitrarily, so the multiplexing of asymmetrical image patterns can be optimized. In particular, we investigate the 90° scheme and the transmission scheme angle multiplexing. For the 90° scheme, a holographic medium with a higher refractive index is recommended for cross talk-limited multiplexing. For the transmission scheme, a holographic medium with a lower refractive index is recommended for angular range-limited multiplexing. In addition, for the transmission scheme, a larger angle between the object arm and the reference arm results in less cross talk noise, whereas the highest storage density is achieved at a 45° angle.