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Fertil Steril. 2011 Apr;95(5):1705-8. doi: 10.1016/j.fertnstert.2011.01.008. Epub 2011 Feb 3.

Sperm chromatin condensation in infertile men with varicocele before and after surgical repair.

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  • 1Department of Dermatology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Abstract

OBJECTIVE:

To assess sperm chromatin integrity in infertile men with varicocele before and after surgical repair.

DESIGN:

Prospective.

SETTING:

Academic setting.

PATIENT(S):

Seventy-two infertile men with varicocele compared with 20 healthy fertile men.

INTERVENTION(S):

History taking, genital examination, semen analysis, sperm chromatin condensation assessment by aniline blue stain before and 3 months after varicocelectomy.

MAIN OUTCOME MEASURE(S):

Stained sperm heads (abnormal chromatin condensation) before and 3 months after varicocelectomy.

RESULT(S):

The mean percentage of aniline blue-stained sperm heads was significantly higher in infertile men with varicocele compared with fertile controls. The mean percentage of stained sperm heads was significantly decreased in infertile men with varicocele 3 months after surgery compared with the preoperative data. There was a significant negative correlation between percentage of stained sperm heads and normal morphology where nonsignificant correlation was elicited regarding sperm count and sperm motility.

CONCLUSION(S):

There is a significant increase of abnormal sperm chromatin condensation in infertile men with varicocele that is markedly improved after varicocelectomy.

Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PMID:
21292253
[PubMed - indexed for MEDLINE]
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