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Genes Dev. 2011 Feb 1;25(3):226-31. doi: 10.1101/gad.1974211.

MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer.

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  • 1Laboratory of Systems Cancer Biology, Rockefeller University, New York, NY 10065, USA.

Abstract

Post-transcriptional regulators have emerged as robust effectors of metastasis and display deregulated expression through unknown mechanisms. Here, we reveal that the human microRNA-335 locus undergoes genetic deletion and epigenetic promoter hypermethylation in every metastatic derivative obtained from independent patients' malignant cell populations. Genetic deletion of miR-335 is a common event in human breast cancer, is enriched for in breast cancer metastases, and also correlates with ovarian cancer recurrence. We furthermore identify miR-335 as a robust inhibitor of tumor reinitiation. We thus implicate the miR-335 locus on 7q32.2 as the first selective metastasis suppressor and tumor initiation suppressor locus in human breast cancer.

PMID:
21289068
[PubMed - indexed for MEDLINE]
PMCID:
PMC3034897
Free PMC Article
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