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Proc Inst Mech Eng H. 2010 Dec;224(12):1441-53.

Focal adhesions in osteoneogenesis.

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  • 1Nanotechnology Center for Mechanics in Regenerative Medicine, Department of Applied Physics and Applied Mathematics, Columbia University, New York 10027, USA.


As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material surface or chemical stimuli in order to help to develop next-generation biomaterials. The focus of this review is on recent studies and developments concerning focal adhesion formation in osteoneogenesis, with an emphasis on the influence of synthetic constructs on integrin-mediated cellular adhesion and function.

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