Fis1, Bap31 and the kiss of death between mitochondria and endoplasmic reticulum

Bing Wang; Mai Nguyen; Natasha C Chang; Gordon C Shore

doi:10.1038/emboj.2010.352

Fis1, Bap31 and the kiss of death between mitochondria and endoplasmic reticulum

EMBO J. 2011 Feb 2;30(3):451-2. doi: 10.1038/emboj.2010.352.

Authors

Bing Wang¹, Mai Nguyen, Natasha C Chang, Gordon C Shore

Affiliation

¹ Department of Biochemistry, Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada.

Abstract

A study in this issue of The EMBO Journal sheds light on how mitochondria–ER dynamics, which affect various cell functions, regulate Bax/Bak-driven apoptosis within the complex milieu of the cell. In cell death, these organelles engage in an unanticipated two-way communication, from mitochondria to ER and back again.

Publication types

Comment

MeSH terms

Apoptosis / physiology*
Endoplasmic Reticulum / metabolism
Endoplasmic Reticulum / physiology*
Membrane Proteins / metabolism*
Mitochondria / metabolism
Mitochondria / physiology*
Mitochondrial Membranes / metabolism*
Mitochondrial Proteins / metabolism*
Models, Biological
Permeability
Signal Transduction / physiology*

Substances

BCAP31 protein, human
FIS1 protein, human
Membrane Proteins
Mitochondrial Proteins