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Alcohol Clin Exp Res. 2011 May;35(5):800-3. doi: 10.1111/j.1530-0277.2010.01401.x. Epub 2011 Feb 1.

Genetics of liver injury and fibrosis.

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  • 1Department of Medicine II, Saarland University Hospital, Homburg, Germany. Susanne.weber@uks.eu


Genetic risk factors play critical roles in liver injury and fibrosis, since both initiation and progression of chronic liver diseases differ between individuals challenged by identical environmental factors. Recently genomewide association studies have identified specific novel risk genes for (non-alcoholic) fatty liver disease (adiponutrin), viral hepatitis (interleukin 28B), and chronic cholestatic diseases (interleukin 12). Here, we summarize these studies and provide an inventory of the susceptibility genes. In the future, risk assessment of complex liver diseases might be based on polygenic risk scores or even gene networks. Complimentary to study in humans, experimental crosses of inbred mouse strains contribute to the genetic dissection of gene-gene interaction and gene-environment interactions. The results of these genomewide studies in mice and men might open new avenues for the prevention and treatment of chronic liver injury and the regression of liver fibrosis.

Copyright © 2011 by the Research Society on Alcoholism.

[PubMed - indexed for MEDLINE]
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