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Pediatr Cardiol. 2011 Mar;32(3):354-9. doi: 10.1007/s00246-010-9877-4. Epub 2011 Jan 29.

Mechanism of cardioprotection: what can we learn from females?

Author information

  • 1NHLBI, NIH, Room 8N202, Building 10, 10 Center Drive, Bethesda, MD, USA. murphy1@mail.nih.gov

Abstract

This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.

PMID:
21279340
[PubMed - indexed for MEDLINE]
PMCID:
PMC3156668
Free PMC Article

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