Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Indian J Pharmacol. 2008 Nov;40(6):248-50. doi: 10.4103/0253-7613.45149.

The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats.

Author information

  • 1Department of Anatomy, Maleka Manipal Medical College, Manipal, India.

Abstract

OBJECTIVE:

To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats.

METHODS:

Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2(nd), 4(th), 5(th), 7(th), 10(th) and 15(th) week, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis.

RESULTS:

The intratesticular testosterone level was significantly (P<0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P<0.001) increased by valproate in a time dependent manner.

CONCLUSION:

Valproate causes reversible change in intratesticular testosterone and LDH level.

KEYWORDS:

Lactate dehydrogenase; sodium valproate; testosterone

PMID:
21279179
[PubMed]
PMCID:
PMC3025140
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Write to the Help Desk