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Nat Genet. 2011 Mar;43(3):185-7. doi: 10.1038/ng.760. Epub 2011 Jan 30.

Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.

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  • 1Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

Abstract

High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.

PMID:
21278746
[PubMed - indexed for MEDLINE]
PMCID:
PMC3076615
Free PMC Article

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