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Cancer Epidemiol Biomarkers Prev. 2011 Mar;20(3):490-500. doi: 10.1158/1055-9965.EPI-10-0820. Epub 2011 Jan 28.

Use of the predictive sugars biomarker to evaluate self-reported total sugars intake in the Observing Protein and Energy Nutrition (OPEN) study.

Author information

  • 1Applied Research Program, Division of Cancer Control and Population Sciences, Nutritional Epidemiology, Branch, National Cancer Institute, 6130 Executive Blvd, EPN/3121, Bethesda, MD 20892, USA. tasevskan@mail.nih.gov

Erratum in

  • Cancer Epidemiol Biomarkers Prev. 2011 Dec;20(12):2646.

Abstract

BACKGROUND:

A predictive biomarker for intake of total sugars was recently developed under controlled conditions. We used this biomarker to assess measurement error (ME) structure in self-reported intake of total sugars in free-living individuals.

METHODS:

The Observing Protein and Energy Nutrition (OPEN) study involved 484 participants aged 40 to 69 years. Diet was assessed using two administrations of a food frequency questionnaire (FFQ) and two nonconsecutive 24-hour dietary recalls (24HDR). Two 24-hour urine samples checked for completeness were analyzed on sucrose and fructose. We applied the biomarker calibrated in a feeding study to OPEN data to assess the ME structure and the attenuation factors (AF) for intakes of absolute total sugars and sugars density for the FFQ and 24HDR.

RESULTS:

The AFs for absolute sugars were similar for a single FFQ and 24HDR, but attenuation decreased with repeated 24HDRs. For sugars density, the AFs for FFQ (men: 0.39; women: 0.33) were greater than for single 24HDR (men: 0.30; women: 0.24), and similar to two 24HDRs (men: 0.41; women: 0.35). The attenuation associated with both instruments was greater in women than in men.

CONCLUSIONS:

Both the FFQ and 24HDR were found to be biased; hence, incorporation of the sugars biomarker in calibration studies within the cohorts may be necessary to more reliably estimate associations of sugars and disease.

IMPACT:

In this article, we propose a new dietary reference instrument based on the recently defined class of predictive biomarkers. Using sugars biomarker, we quantify ME in the FFQ- and 24HDR-reported absolute total sugars and total sugars density.

©2011 AACR.

PMID:
21278329
[PubMed - indexed for MEDLINE]
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