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Clin Gastroenterol Hepatol. 2011 May;9(5):395-9. doi: 10.1016/j.cgh.2011.01.019. Epub 2011 Jan 28.

Do not assume symptoms indicate failure of anti-tumor necrosis factor therapy in Crohn's disease.

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  • 1Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.


It is a challenge to monitor patients with Crohn's disease who remain symptomatic despite anti-tumor necrosis factor therapy. Clinicians must use a systematic approach for each patient and obtain objective evidence about disease activity and response to therapy. Alternate etiologies for symptoms should be sought and treated, if found. Active Crohn's disease despite therapy requires reassessment and adjustments to management plans.

Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.

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