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Curr Opin Genet Dev. 2011 Jun;21(3):325-32. doi: 10.1016/j.gde.2011.01.005. Epub 2011 Jan 27.

Epilepsy genetics--past, present, and future.

Author information

  • 1Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children's Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Fegan 9, Boston, MA 02115, United States. annapuma.poduri@childrens.harvard.edu

Abstract

Human epilepsy is a common and heterogeneous condition in which genetics play an important etiological role. We begin by reviewing the past history of epilepsy genetics, a field that has traditionally included studies of pedigrees with epilepsy caused by defects in ion channels and neurotransmitters. We highlight important recent discoveries that have expanded the field beyond the realm of channels and neurotransmitters and that have challenged the notion that single genes produce single disorders. Finally, we project toward an exciting future for epilepsy genetics as large-scale collaborative phenotyping studies come face to face with new technologies in genomic medicine.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21277190
[PubMed - indexed for MEDLINE]
PMCID:
PMC4074083
Free PMC Article
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