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Immunol Today. 1990 Dec;11(12):443-9.

Biological and clinical aspects of interleukin 6.

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  • 1Division of Immunology, Osaka University, Japan.

Abstract

Interleukin 6 (IL-6) is a multi-functional cytokine that is produced by a range of cells and plays a central role in host defense mechanisms. Abnormal production of IL-6 has been suggested to be involved in glomerulonephritis, plasmacytomagenesis and in the pathogenesis of autoimmune diseases. In this review, Toshio Hirano and colleagues discuss the possible involvement of IL-6 in a variety of diseases, the regulatory mechanism(s) of expression of the IL-6 gene and the structure and function of the IL-6 receptor.

Comment in

  • Further functions of IL-6. [Immunol Today. 1991]
PMID:
2127356
[PubMed - indexed for MEDLINE]
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