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Am J Infect Control. 2011 Apr;39(3):247-9. doi: 10.1016/j.ajic.2010.06.027. Epub 2011 Jan 26.

Vaccine-related varicella-zoster rash in a hospitalized immunocompetent patient.

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  • 1Department of Infection Prevention and Control, New York Presbyterian Hospital, NY 10032, USA.


An immunocompetent health care worker with no known history of varicella-zoster virus (VZV) disease was exposed to a patient with herpes zoster and was immunized 2 days later. Twenty-seven days after receiving the varicella vaccine, while hospitalized, she developed a disseminated rash. This exposure and subsequent development of symptoms posed infection control challenges. A polymerase chain reaction analysis of her vesicular fluid was positive for vaccine-type VZV, and a blood specimen collected before vaccination demonstrated a positive VZV titer by the fluorescent antibody to membrane antigen test. To the best of our knowledge, there have been no previous reports of an immunocompetent seropositive person developing vaccine-type VZV after receiving the vaccine.

Copyright © 2011 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

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