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J Cataract Refract Surg. 2011 Mar;37(3):569-73. doi: 10.1016/j.jcrs.2010.09.020. Epub 2011 Jan 22.

Management of pain with diclofenac after femtosecond-assisted laser in situ keratomileusis.

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  • 1Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Abstract

PURPOSE:

To evaluate the safety and efficacy of topical diclofenac sodium 0.1% after femtosecond laser-assisted laser in situ keratomileusis (LASIK).

SETTING:

W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.

DESIGN:

Clinical trial.

METHODS:

Pain was assessed in patients treated with topical diclofenac sodium 0.1% or artificial tears immediately after LASIK using a numeric pain scale and a combined picture-numeric pain scale 0, 2, 4, 12, and 24 hours postoperatively. Visual outcomes and complications were noted up to 24 hours.

RESULTS:

The study enrolled 100 eyes of 50 patients. Patients treated with diclofenac 0.1% reported less pain than the control group on both pain scales 2, 4, 12, and 24 hours after surgery, with the maximum benefit at 4 hours (P=.02). Fewer patients in the diclofenac group (76.0%) than in the control group (91.3%) used oral pain and/or anxiolytic medications during the first 24 hours after surgery (P=.25). Ninety-eight eyes had an uncorrected distance visual acuity of 20/40 or better. Mild peripheral diffuse lamellar keratitis accounted for the majority of perioperative complications (n = 15).

CONCLUSION:

Pain after femtosecond laser-assisted LASIK was mild and was reduced with a single dose of topical diclofenac sodium 0.1% given immediately after surgery.

Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

PMID:
21262562
[PubMed - indexed for MEDLINE]
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