Format

Send to:

Choose Destination
See comment in PubMed Commons below
Ann N Y Acad Sci. 2011 Jan;1215:89-95. doi: 10.1111/j.1749-6632.2010.05864.x.

Chemopreventive effects of resveratrol and resveratrol derivatives.

Author information

  • 1Institute for Laboratory Medicine, Department for Medical, Medical University of Vienna, General Hospital of Vienna, Austria. thomas.szekeres@meduniwien.ac.at

Abstract

Resveratrol is considered to have a number of beneficial effects. Recently, our group modified the molecule and synthesized a number of compounds with different biochemical effects. Polymethoxy and polyhydroxy derivatives of resveratrol were shown to inhibit tumor cell growth in various cell lines and inflammation pathways (cyclooxygenases activity), in part more effectively than resveratrol itself. One lead compound (hexahydroxystilbene, M8) turned out to be the most effective inhibitor of tumor cell growth and of cyclooxygenase 2 activity. M8 was then studied in two different human melanoma mouse models. This novel resveratrol analog was able to inhibit melanoma tumors in a primary tumor model alone and in combination with dacarbacine, an anticancer compound that is used for melanoma treatment. We also tested the development of lymph node metastasis in a second melanoma model and again M8 successfully inhibited the tumor as well as the size and weight of lymph node metastasis. Hydroxylated resveratrol analogs therefore represent a novel class of anticancer compounds and promising candidates for in vivo studies.

© 2011 New York Academy of Sciences.

PMID:
21261645
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk