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Biomed Opt Express. 2010 Jul 15;1(1):126-134.

Improved detection limits using a hand-held optical imager with coregistration capabilities.

Author information

  • 1Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street EC2610; Miami, FL 33174, USA.

Abstract

Optical imaging is emerging as a non-invasive and non-ionizing method for breast cancer diagnosis. A hand-held optical imager has been developed with coregistration facilities towards flexible imaging of different tissue volumes and curvatures in near real-time. Herein, fluorescence-enhanced optical imaging experiments are performed to demonstrate deeper target detection under perfect and imperfect (100:1) uptake conditions in (liquid) tissue phantoms and in vitro. Upon summation of multiple scans (fluorescence intensity images), fluorescent targets are detected at greater depths than from single scan alone.

PMID:
21258452
[PubMed - as supplied by publisher]
PMCID:
PMC3005178
Free PMC Article

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