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J Biol Chem. 2011 Mar 25;286(12):9941-7. doi: 10.1074/jbc.R110.198697. Epub 2011 Jan 21.

Signaling to myosin regulatory light chain in sarcomeres.

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  • 1Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.


Myosin regulatory light chain (RLC) phosphorylation in skeletal and cardiac muscles modulates Ca(2+)-dependent troponin regulation of contraction. RLC is phosphorylated by a dedicated Ca(2+)-dependent myosin light chain kinase in fast skeletal muscle, where biochemical properties of RLC kinase and phosphatase converge to provide a biochemical memory for RLC phosphorylation and post-activation potentiation of force development. The recent identification of cardiac-specific myosin light chain kinase necessary for basal RLC phosphorylation and another potential RLC kinase (zipper-interacting protein kinase) provides opportunities for new approaches to study signaling pathways related to the physiological function of RLC phosphorylation and its importance in cardiac muscle disease.

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