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Am J Obstet Gynecol. 2011 Apr;204(4):364.e17-24. doi: 10.1016/j.ajog.2010.11.015. Epub 2011 Jan 22.

Fetal responses to lipopolysaccharide-induced chorioamnionitis alter immune and airway responses in 7-week-old sheep.

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  • 1School of Women's and Infant's Health, The University of Western Australia, Perth, Australia.

Abstract

OBJECTIVE:

We hypothesized that fetal innate immune responses to lipopolysaccharide-induced chorioamnionitis would alter postnatal systemic immune and airway responsiveness.

STUDY DESIGN:

Ewes received intraamniotic injections with saline or lipopolysaccharide at 90, 100, and 110 days of gestation. Immune status and airway responsiveness were evaluated at term and at 7 weeks of age.

RESULTS:

At term, lymphocytes, monocytes, and neutrophils were significantly increased (respectively, 24-fold, 127-fold, and 31,000-fold) in lungs and blood monocytes became Toll-like receptor 2 responsive after lipopolysaccharide exposures. Furthermore, CD4 and CD4/CD25 lymphocytes were increased in thymus and lymph nodes. At 7 weeks, airway reactivity decreased and concentrations of CD8 cytotoxic T lymphocytes changed in the lungs and thymus relative to controls.

CONCLUSION:

Early gestational lipopolysaccharide exposure increased leukocyte responsiveness at term. Decreased airway reactivity and changes in lymphocytes at 7 weeks postnatal demonstrate persistent effects of fetal exposure to LPS.

Copyright © 2011 Mosby, Inc. All rights reserved.

PMID:
21257142
[PubMed - indexed for MEDLINE]
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