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J Pak Med Assoc. 1990 Jul;40(7):154-6.

A placebo controlled trial of bismuth salicylate in Helicobacter pylori associated gastritis.

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  • 1Department of Pathology, Pakistan Medical Research Council, Karachi.


In a placebo controlled prospective clinical trial of bismuth salicylate in helicobacter pylori associated gastritis, 52 adult patients were randomly allocated to treatment with bismuth salicylate or placebo. Helicobacter pylori were totally cleared in 77% patients in bismuth group but none in placebo group (P less than 0.001). Resolution of gastritis (P less than 0.001) and improvement of symptoms (P less than 0.01) were significantly better in patients where H. pylori infection cleared as compared to patients where the infection persisted.

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