Abstract
From the seed pods of Bauhinia retusa, a new eudesmane sesquiterpene glucoside, 1-O-β-D-glucopyranosyl-9β,15-dihydroxy-5α,6βH-eudesma-3-ene-6α,12-olide (1), has been isolated together with three known compounds, 4'-hydroxy-7-methoxy flavane (2), β-sitosterol (3), and stigmasterol (4). The structures of isolated compounds were verified with the help of 1D, 2D NMR, and HR-ESI-MS spectroscopies. Compound 1 showed moderate antibacterial activity against Pseudomonas aeruginosa and Escherichia coli when a disc diffusion method is used.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Bauhinia / chemistry*
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Escherichia coli / drug effects
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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India
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pseudomonas aeruginosa / drug effects
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Salmonella typhi / drug effects
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Seeds / chemistry
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Sesquiterpenes, Eudesmane / chemistry
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Sesquiterpenes, Eudesmane / isolation & purification*
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Sesquiterpenes, Eudesmane / pharmacology*
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Staphylococcus aureus / drug effects
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Stereoisomerism
Substances
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1-O-beta-D-glucopyranosyl-9beta,15-dihydroxy-5alpha,6betaH-eudesma-3-ene-6alpha,12-olide
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Anti-Bacterial Agents
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Glucosides
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Lactones
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Sesquiterpenes, Eudesmane