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Am J Dermatopathol. 2011 Apr;33(2):195-8. doi: 10.1097/DAD.0b013e3181eb2f66.

Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance?

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  • 1Dermatopathology Unit, San Gallicano Dermatological Institute, Rome, Italy.


A 58-year-old white woman with stasis dermatitis developed a solitary, slowly growing keratotic nodule of the dorsum of the foot. The excision biopsy specimen of this lesion showed a biphasic pattern of eccrine syringofibroadenoma and clear cell acanthoma. Such a previously unreported association is neither necessarily by chance nor necessarily a collision. Because a reactive histogenesis has been postulated for both eccrine syringofibroadenoma and clear cell acanthoma, this case could represent a morphologically biphasic pattern of epidermal and ductal hyperplasia as a consequence of the stasis-induced chronic inflammation coupled with the footwear-induced chronic trauma.

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