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Curr Opin Genet Dev. 2011 Jun;21(3):349-53. doi: 10.1016/j.gde.2010.12.007. Epub 2011 Jan 19.

Genetic modifiers of neurological disease.

Author information

  • Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, 529 Light Hall, 2215 Garland Ave, Nashville, TN 37232-0275, USA. jennifer.kearney@vanderbilt.edu

Abstract

Genetic modifiers make an important contribution to neurological disease phenotypes. Significant progress has been made by studying genetic modifiers in model organisms. The ability to study complex genetic interactions in model systems contributes to our understanding of the genetic factors that influence neurological disease. This will lead to the development of novel therapeutic strategies and personalized treatment based on genetic risk.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
21251811
[PubMed - indexed for MEDLINE]
PMCID:
PMC3105121
Free PMC Article

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