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Clin Exp Pharmacol Physiol. 2012 Jan;39(1):96-103. doi: 10.1111/j.1440-1681.2011.05482.x.

Renal inflammation, autoimmunity and salt-sensitive hypertension.

Author information

  • 1Renal Service, University Hospital, University of Zulia and Venezuelan Institute of Scientific Research-Zulia, Maracaibo, Estado Zulia, Venezuela. brodrigueziturbe@gmail.com

Abstract

1. The present article reviews the role of immune-competent cells infiltrating the kidney and their association with oxidative stress and renal angiotensin activity in the development of salt-sensitive hypertension. 2. We discuss changes in the pressure-natriuresis relationship resulting from renal inflammation and its improvement resulting from immunosuppressive treatment. 3. The potential role of T-cell-driven reactivity in sustaining the renal inflammation is examined in the light of accumulating evidence of autoimmune mechanisms in experimental and clinical hypertension.

© 2011 The Authors. Clinical and Experimental Pharmacology and Physiology © 2011 Blackwell Publishing Asia Pty Ltd.

PMID:
21251049
[PubMed - indexed for MEDLINE]
PMCID:
PMC3137657
Free PMC Article
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