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Curr Opin Psychiatry. 2011 Mar;24(2):122-7. doi: 10.1097/YCO.0b013e3283436eb7.

Brain-derived neurotrophic factor: findings in schizophrenia.

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  • 1Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia, USA.



To review the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity related to schizophrenia and the recent findings that have been reported on the status of BDNF in patients with schizophrenia and its association with the clinical measures.


Peripheral BDNF levels have been found altered in first-episode patients with psychosis and also in chronic schizophrenia patients. A few studies have reported changes in peripheral BDNF levels following antipsychotic treatment. The role of Val66Met polymorphism in BDNF has been shown to play an important role in structural and functional plasticity in schizophrenia.


Although peripheral BDNF levels hold promise for providing new perspectives for the development of novel therapeutic strategies for the treatment of schizophrenia, additional studies including efforts to prove its potential as a biomarker are warranted.

[PubMed - indexed for MEDLINE]
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